Article
Re-evaluation of the probabilities for productive arrangements on the kappa and lambda loci.
International immunology - 1 Jan 1996
Arakawa H, Shimizu T, Takeda S
Abstract excerpt
V-J arrangements at Ig light chain (IgL) genes occur in resting small pre-B cells. In the absence of cell division, the probability of production kappa and lambda rearrangements is proportional to the output of kappa+ B and lambda+ B cells in bone marrow. The kinetics and probability of productive kappa or lambda rearrangements was assessed in three groups of mice carrying two (wild-type), one or no intact...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.