Article
Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127.
Antiviral research - 1 Dec 1995
Zhang H, Vrang L, Bäckbro K, Lind P, Sahlberg C, Unge T, Oberg B
Abstract excerpt
A new class of very potent and selective non-nucleoside inhibitors of HIV reverse transcriptase (RT) has recently been identified. The prototype compound trovirdine (LY 300046 HCl) and one analogue, MSC-127, have been studied with respect to inhibition of wild-type HIV-1 RT and RT with various mu...
Topics
- Antiviral Agents
- Base Sequence
- Enzyme Activation
- HIV Reverse Transcriptase
- HIV-1
- Kinetics
- Molecular Sequence Data
- Mutation
- Pyridines
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors
- Thiourea