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Article

Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.

Journal of medicinal chemistry - 30 Jul 1998

Cywin C L, Klunder J M, Hoermann M, Brickwood J R, David E, Grob P M, Schwartz R, Pauletti D, Barringer K J, Shih C K, Sorge C L, Erickson D A, Joseph D P, Hattox S E

Abstract excerpt

Nevirapine (I) is the first human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitor to reach regulatory approval. As a result of a second generation program around the tricyclic core system of nevirapine, 2-chloro-5, 11-dihydro-11-ethyl-5-methyl-8-(2-(pyridin-4-yl)ethyl)-6H-dipyrido[3, 2-b:2',3'-e][1,4]diazepin-6-one (II)1a and 2-chloro-5,...

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Identifiers

PMID: 9685236
DOI: 10.1021/jm9707030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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