Article
Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.
Journal of medicinal chemistry - 30 Jul 1998
Cywin C L, Klunder J M, Hoermann M, Brickwood J R, David E, Grob P M, Schwartz R, Pauletti D, Barringer K J, Shih C K, Sorge C L, Erickson D A, Joseph D P, Hattox S E
Abstract excerpt
Nevirapine (I) is the first human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitor to reach regulatory approval. As a result of a second generation program around the tricyclic core system of nevirapine, 2-chloro-5, 11-dihydro-11-ethyl-5-methyl-8-(2-(pyridi...
Topics
- Animals
- Antiviral Agents
- Azepines
- Biological Availability
- Cell Line, Transformed
- Cell Survival
- Drug Evaluation, Preclinical
- Drug Resistance, Microbial
- Drug Stability
- HIV Reverse Transcriptase
- HIV-1
- Humans
- In Vitro Techniques