Article
Anti-human immunodeficiency virus type 1 activity of novel 6-substituted 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives.
Antimicrobial agents and chemotherapy - 1 May 2012
Ordonez Paula, Hamasaki Takayuki, Isono Yohei, Sakakibara Norikazu, Ikejiri Masahiro, Maruyama Tokumi, Baba Masanori
Abstract excerpt
Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) are important components of current combination therapies for human immunodeficiency virus type 1 (HIV-1) infection. In screening of chemical libraries, we found 6-azido-1-benzyl-3-(3,5-dimethylbenzyl)uracil (AzBBU) and 6-amino-1-benzyl-3-(3,5-dimethylbenzyl)uracil (AmBBU) to be highly active and selective inhibitors of HIV-1 replication in vitro. To...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Anti-HIV Agents
- Binding Sites
- Cell Line
- Computer Simulation
- Drug Resistance, Viral
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation