Article
Enzymatic properties and sensitivity to inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with Glu-138-->Arg and Tyr-188-->His mutations.
Antiviral research - 1 May 1994
Zhang H, Vrang L, Bäckbro K, Unge T, Noréen R, Oberg B
Abstract excerpt
Two mutants of HIV-1 reverse transcriptase (RT), Tyr-188-->His and Glu-138-->Arg have been prepared and their catalytic properties and sensitivities to inhibitors studied. As compared to wild type RT, a reduction in catalytic efficiency and turn over number was observed, especially for the Tyr-18...
Topics
- Amino Acids
- Antiviral Agents
- Base Sequence
- Benzodiazepines
- Benzoxazoles
- Binding, Competitive
- Deoxyguanine Nucleotides
- Dideoxynucleotides
- Foscarnet
- HIV Reverse Transcriptase
- Humans
- Imidazoles
- Kinetics
- Molecular Sequence Data
- Mutation
- Nevirapine
- Pyridines
- Pyridones