Viral resistance to the thiazolo-iso-indolinones, a new class of nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase.

doi:10.1128/AAC.37.12.2612

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Article

Viral resistance to the thiazolo-iso-indolinones, a new class of nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase.

Antimicrobial agents and chemotherapy - 1 Dec 1993

Maass G, Immendoerfer U, Koenig B, Leser U, Mueller B, Goody R, Pfaff E

Abstract excerpt

Thiazolo-iso-indolinone derivatives with high specificity toward the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) were identified. The most potent compound, BM +51.0836, inhibited HIV-1 RT at a 50% inhibitory concentration of 90 nM in vitro. In cell culture assays, si...

Topics

Antiviral Agents
Base Sequence
Cells, Cultured
Drug Resistance, Microbial
Enzyme-Linked Immunosorbent Assay
HIV Reverse Transcriptase
HIV-1
Humans
Indoles
Isoindoles
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

RNA-Directed DNA Polymerase

Recombinant Fusion Proteins

Reverse Transcriptase Inhibitors

Thiazoles

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 7509144
DOI: 10.1128/AAC.37.12.2612
PMCID: PMC192754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7509144-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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