Article
The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.
Journal of virology - 1 Jul 2004
Auwerx Joeri, Stevens Miguel, Van Rompay An R, Bird Louise E, Ren Jingshan, De Clercq Erik, Oberg Bo, Stammers David K, Karlsson Anna, Balzarini Jan
Abstract excerpt
The phenylmethylthiazolylthiourea (PETT) derivative MSK-076 shows, besides high potency against human immunodeficiency virus type 1 (HIV-1), marked activity against HIV-2 (50% effective concentration, 0.63 microM) in cell culture. Time-of-addition experiments pointed to HIV-2 reverse transcriptase (RT) as the target of action of MSK-076. Recombinant HIV-2 RT was inhibited by MSK-076 at 23 microM. As was also...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.