Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells.

Article

Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells.

Cancer research - 15 Sept 1994

Houghton J A, Harwood F G, Houghton P J

Abstract excerpt

Thymidylate synthase (TS) is a target of critical importance to the survival of human colon cancer cells since, upon inhibition, cells subsequently undergo thymineless death induced by dTTP deficiency. Using genetically marked mutants deficient in TS (TS-) and a derived population (Thy4) that is...

Topics

Adenocarcinoma
Apoptosis
Cell Cycle
Cell Survival
Colonic Neoplasms
G1 Phase
Humans
Leucine
Phenotype
Resting Phase, Cell Cycle
S Phase
Thymidine
Thymidylate Synthase
Time Factors
Tumor Cells, Cultured

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