Article
A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles.
International immunology - 1 Nov 2010
Butler Marcus O, Ansén Sascha, Tanaka Makito, Imataki Osamu, Berezovskaya Alla, Mooney Mary M, Metzler Genita, Milstein Matthew I, Nadler Lee M, Hirano Naoto
Abstract excerpt
Many preclinical experiments have attested to the critical role of CD4(+) T cell help in CD8(+) cytotoxic T lymphocyte (CTL)-mediated immunity. Recent clinical trials have demonstrated that reinfusion of CD4(+) T cells can induce responses in infectious diseases and cancer. However, few standardized and versatile systems exist to expand antigen-specific CD4(+) T(h) for clinical use. K562 is a human...
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