Article
Artificial antigen-presenting cells expressing HLA class II molecules as an effective tool for amplifying human specific memory CD4(+) T cells.
Immunology and cell biology - 1 Aug 2016
Garnier Anthony, Hamieh Mohamad, Drouet Aurélie, Leprince Jérôme, Vivien Denis, Frébourg Thierry, Le Mauff Brigitte, Latouche Jean-Baptiste, Toutirais Olivier
Abstract excerpt
Owing to their multiple immune functions, CD4(+) T cells are of major interest for immunotherapy in chronic viral infections and cancer, as well as for severe autoimmune diseases and transplantation. Therefore, standardized methods allowing rapid generation of a large number of CD4(+) T cells for adoptive immunotherapy are still awaited. We constructed stable artificial antigen-presenting cells (AAPCs) derived...
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