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Article

CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996

Chapman A, Stewart S J, Nepom G T, Green W F, Crowe D, Thomas J W, Miller G G

Abstract excerpt

Engagement of CD28 induces a major costimulatory pathway required by many CD4+ T cells in addition to activation via the TCR. In the absence of signals provided by CD28, ligation of the TCR alone can induce anergy or apoptosis in CD28+ cells. However, we report here characterization of a distinct subset of CD4+ T cells that are CD28-. Three autoreactive CD4+ human T cell clones that could be activated to produce...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8943378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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