In vitro selection and characterization of VX-478 resistant HIV-1 variants.

doi:10.1007/978-1-4615-5373-1_10

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Article

In vitro selection and characterization of VX-478 resistant HIV-1 variants.

Advances in experimental medicine and biology - 1 Jan 1998

Pazhanisamy S, Partaledis J A, Rao B G, Livingston D J

Abstract excerpt

VX-478 (141W94), a potent inhibitor of HIV protease, is in late stage clinical trials for the treatment of HIV infection and AIDS. Resistant viruses were raised in vitro by passage of HIV-1IIIB in the presence of increasing concentrations of VX-478 and the related hydroxyethylamino sulfonamide in...

Topics

Carbamates
Drug Resistance
Furans
Genetic Variation
HIV Protease
HIV Protease Inhibitors
HIV-1
Humans
Mutation
Protein Conformation
Sulfonamides

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