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Article

Kinetic properties of saquinavir-resistant mutants of human immunodeficiency virus type 1 protease and their implications in drug resistance in vivo.

Biochemistry - 7 Oct 1997

Ermolieff J, Lin X, Tang J

Abstract excerpt

In order to study the basis of resistance of human immunodeficiency virus, type 1 (HIV-1), to HIV-1 protease inhibitor saquinavir, the catalytic and inhibition properties of the wild-type HIV-1 protease and three saquinavir resistant mutants, G48V, L90M, and G48V/L90M, were compared. The kinetic...

Topics

Dose-Response Relationship, Drug
Drug Resistance, Microbial
Genotype
HIV Protease
HIV Protease Inhibitors
Humans
Kinetics
Mutagenesis, Site-Directed
Protein Processing, Post-Translational
Saquinavir
Substrate Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virion

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Identifiers

PMID: 9315877
DOI: 10.1021/bi971072e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9315877-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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