Article
Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them.
The Journal of biological chemistry - 10 Nov 2000
Zhang Y, Redina O, Altshuller Y M, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman M A
Abstract excerpt
Phospholipase D (PLD), a signal-transducing membrane-associated enzyme, is implicated in diverse processes including apoptosis, ERK activation, and glucose transport. Prior studies have identified specific PLD activators and repressors that directly regulate its enzymatic activity. Using two-hybrid screens, we have identified PEA-15 as a PLD interactor that unexpectedly functions to alter its level of expression....
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