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Article

Gain-of-function Chinese hamster ovary mutants LEC18 and LEC14 each express a novel N-acetylglucosaminyltransferase activity.

The Journal of biological chemistry - 5 Jun 1998

Raju T S, Stanley P

Abstract excerpt

LEC18 and LEC14 cells are gain-of-function glycosylation mutants isolated from Chinese hamster ovary cells for resistance to pea lectin. Structural studies have shown that LEC18 cells synthesize complex N-glycans with a GlcNAc residue linked at the O-6 position of the core GlcNAc (Raju, T. S., Ray, M. K., and Stanley, P. (1995) J. Biol. Chem. 270, 30294-30302), whereas LEC14 cells synthesize complex N-glycans...

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PMID: 9603907
DOI: 10.1074/jbc.273.23.14090

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Gain-of-function Chinese hamster ovary mutants LEC18 and LEC14 each express a novel N-acetylglucosaminyltransferase activity.PMID 9603907Read ↗

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CHO cells provide access to novel N-glycans and developmentally regulated glycosyltransferases.Semantic proximity Read ↗

LEC18, a dominant Chinese hamster ovary glycosylation mutant synthesizes N-linked carbohydrates with a novel core structure.Semantic proximity Read ↗

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