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Article

Effects of truncation of the COOH-terminal region of a Na+-independent neutral and basic amino acid transporter on amino acid transport in Xenopus oocytes.

The Journal of biological chemistry - 12 Jul 1996

Miyamoto K, Segawa H, Tatsumi S, Katai K, Yamamoto H, Taketani Y, Haga H, Morita K, Takeda E

Abstract excerpt

To determine the role of a neutral and basic amino acid transporter (NBAT) in amino acid transport, we microinjected several COOH-terminal deletion mutants of NBAT cRNA into Xenopus oocytes and measured transport activity for arginine, leucine, and cystine in the presence and absence of sodium. Wild-type NBAT significantly stimulated the uptake of all three amino acids 10-20-fold compared with controls. On the...

Topics

Amino Acid Sequence
Amino Acid Transport Systems
Amino Acid Transport Systems, Basic
Amino Acids
Animals
Biological Transport
Carrier Proteins
Cloning, Molecular
DNA, Complementary
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kidney Cortex

Membrane Potentials

Membrane Proteins

Molecular Sequence Data

Mutation

Oocytes

Sequence Deletion

Source

Identifiers

PMID: 8663184
DOI: 10.1074/jbc.271.28.16758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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