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Article

Cationic amino acids involved in dicarboxylate binding of the flounder renal organic anion transporter.

Journal of the American Society of Nephrology : JASN - 1 Oct 2001

Wolff Natascha A, Grünwald Bettina, Friedrich Björn, Lang Florian, Godehardt Stefan, Burckhardt Gerhard

Abstract excerpt

Three conserved cationic amino acids in predicted transmembrane domains 1, 8, and 11, respectively, of the flounder renal organic anion transporter, fROAT, were changed by site-directed mutagenesis and the resulting mutants functionally characterized in Xenopus laevis oocytes. Uptake of p-aminohippurate (PAH) in oocytes that expressed mutant H34I, K394A, or R478D was markedly reduced compared with oocytes that...

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PMID: 11562399
DOI: 10.1681/ASN.V12102012

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PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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