Article
A novel role of the C-terminus of b 0,+ AT in the ER-Golgi trafficking of the rBAT-b 0,+ AT heterodimeric amino acid transporter.
The Biochemical journal - 15 Jan 2009
Sakamoto Shinichi, Chairoungdua Arthit, Nagamori Shushi, Wiriyasermkul Pattama, Promchan Kanyarat, Tanaka Hidekazu, Kimura Toru, Ueda Takeshi, Fujimura Masaaki, Shigeta Yasuhiro, Naya Yukio, Akakura Koichiro, Ito Haruo, Endou Hitoshi, Ichikawa Tomohiko, Kanai Yoshikatsu
Abstract excerpt
The heterodimeric complex composed of rBAT (related to b(0,+) amino acid transporter), a single-membrane-spanning glycosylated heavy chain, and b(0,+)AT, a putative 12-membrane-spanning non-glycosylated light chain, is an amino acid transporter that mediates the activity of system b(0,+), a major apical transport system for cystine and dibasic amino acids in renal proximal tubule and small intestine. The...
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