Article
Cystinuria-specific rBAT(R365W) mutation reveals two translocation pathways in the amino acid transporter rBAT-b0,+AT.
The Biochemical journal - 1 Feb 2004
Pineda Marta, Wagner Carsten A, Bröer Angelika, Stehberger Paul A, Kaltenbach Simone, Gelpí Josep Ll, Martín Del Río Rafael, Zorzano Antonio, Palacín Manuel, Lang Florian, Bröer Stefan
Abstract excerpt
Apical reabsorption of dibasic amino acids and cystine in kidney is mediated by the heteromeric amino acid antiporter rBAT/b(0,+)AT (system b(0,+)). Mutations in rBAT cause cystinuria type A, whereas mutations in b(0,+)AT cause cystinuria type B. b(0,+)AT is the catalytic subunit, whereas it is believed that rBAT helps the routing of the rBAT/b(0,+)AT heterodimeric complex to the plasma membrane. In the present...
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