Article
The Sp4H deletion may contain a new locus essential for postimplantation development.
Genomics - 1 Jun 1996
Fleming J, Pearce A, Brown S D, Steel K P
Abstract excerpt
Sp4H is a semi-dominant mutation that maps to mouse chromosome 1. Heterozygous mice exhibit white spotting of the belly, whereas the fate of the homozygous embryos is unknown. We have previously shown that the entire coding region of the Pax3 gene is deleted in the Sp4H mutant. In this study, we have analyzed the fate of the Sp4H homozygous embryos. No Sp4H homozygotes were detected by Southern blot or PCR...
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