Article
Profiling of early gene expression induced by erythropoietin receptor structural variants.
The Journal of biological chemistry - 24 Mar 2006
Büchse Tom, Prietzsch Holger, Sasse Tilo, Körbel Sandra, Stigge Gunnar, Bogdanow Simon, Brock Josef, Bittorf Thomas
Abstract excerpt
The development of erythroid progenitor cells is triggered via the expression of the erythropoietin receptor (EPOR) and its activation by erythropoietin. The function of the resulting receptor complex depends critically on the presence of activated JAK2, and the complex contains a large number of signaling molecules recruited to eight phosphorylated tyrosine residues. Studies using mutant receptor forms have...
Topics
- Animals
- Apoptosis
- Binding Sites
- Blotting, Northern
- Cell Proliferation
- DNA, Complementary
- Dose-Response Relationship, Drug
- Erythropoiesis
- Gene Expression Profiling
- Gene Expression Regulation
- Genetic Variation
- Immunoblotting
- Janus Kinase 2