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Article

Complementation of the beige mutation in cultured cells by episomally replicating murine yeast artificial chromosomes.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 1996

Perou C M, Justice M J, Pryor R J, Kaplan J

Abstract excerpt

Chédiak-Higashi syndrome in man and the beige mutation of mice are phenotypically similar disorders that have profound effects upon lysosome and melanosome morphology and function. We isolated two murine yeast artificial chromosomes (YACs) that, when introduced into beige mouse fibroblasts, compl...

Topics

Animals
Cells, Cultured
Chediak-Higashi Syndrome
Chromosomes, Artificial, Yeast
Fibroblasts
Genetic Complementation Test
Genetic Vectors
Humans
Mice
Mink
Mutation
Pigmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8650191
DOI: 10.1073/pnas.93.12.5905
PMCID: PMC39160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8650191-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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