Article
Identification of the murine beige gene by YAC complementation and positional cloning.
Nature genetics - 1 Jul 1996
Perou C M, Moore K J, Nagle D L, Misumi D J, Woolf E A, McGrail S H, Holmgren L, Brody T H, Dussault B J, Monroe C A, Duyk G M, Pryor R J, Li L, Justice M J, Kaplan J
Abstract excerpt
The beige mutation is a murine autosomal recessive disorder, resulting in hypopigmentation, bleeding and immune cell dysfunction. The gene defective in beige is thought to be a homologue of the gene for the human disorder Chediak-Higashi syndrome. We have identified the murine beige gene by in vitro complementation and positional cloning, and confirmed its identification by defining mutations in two independent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.