Article
Identification of the murine beige gene by YAC complementation and positional cloning.
Nature genetics - 1 Jul 1996
Perou C M, Moore K J, Nagle D L, Misumi D J, Woolf E A, McGrail S H, Holmgren L, Brody T H, Dussault B J, Monroe C A, Duyk G M, Pryor R J, Li L, Justice M J, Kaplan J
Abstract excerpt
The beige mutation is a murine autosomal recessive disorder, resulting in hypopigmentation, bleeding and immune cell dysfunction. The gene defective in beige is thought to be a homologue of the gene for the human disorder Chediak-Higashi syndrome. We have identified the murine beige gene by in vi...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chediak-Higashi Syndrome
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Cloning, Molecular
- Genetic Complementation Test
- Humans
- Intracellular Signaling Peptides and Proteins
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains