Article
YAC rescue of downless locus mutations in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Nov 1998
Majumder K, Shawlot W, Schuster G, Harrison W, Elder F F, Overbeek P A
Abstract excerpt
Mice with mutations at the downless (dl) locus have defects in hair follicle, tooth, sweat gland, preputial gland, Meibomian gland, and tail development. The dl phenotype is analogous to the human genetic disorder termed autosomal hypohidrotic (or anhidrotic) ectodermal dysplasia (HED). On the ba...
Topics
- Alleles
- Animals
- Chromosomes, Artificial, Yeast
- Disease Models, Animal
- Ectodermal Dysplasia
- Humans
- In Situ Hybridization, Fluorescence
- Mice
- Mice, Transgenic
- Mutagenesis, Insertional
- Pedigree
- Phenotype