Article
Human p57(KIP2) defines a new imprinted domain on chromosome 11p but is not a tumour suppressor gene in Wilms tumour.
Oncogene - 13 Mar 1997
Taniguchi T, Okamoto K, Reeve A E
Abstract excerpt
Mouse p57(Kip2) arrests cells in G1 by functioning as a strong inhibitor of several G1 cyclin/Cdk complexes (Lee et al., 1995; Matsuoka et al., 1995; Sherr and Roberts, 1995). Human p57(KIP2) has been suggested to be a tumour suppressor gene because of its location at 11p15.5 which frequently und...
Topics
- Adult
- Alleles
- Child
- Chromosomes, Human, Pair 11
- Cyclin-Dependent Kinase Inhibitor p57
- Female
- Gene Deletion
- Gene Expression
- Genes, Tumor Suppressor
- Genomic Imprinting
- Heterozygote
- Humans
- Male
- Nuclear Proteins
- Polymerase Chain Reaction
- Transcription, Genetic
- Wilms Tumor