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Article

Genomic imprinting of human p57KIP2 and its reduced expression in Wilms' tumors.

Human molecular genetics - 1 Jun 1996

Hatada I, Inazawa J, Abe T, Nakayama M, Kaneko Y, Jinno Y, Niikawa N, Ohashi H, Fukushima Y, Iida K, Yutani C, Takahashi S, Chiba Y, Ohishi S, Mukai T

Abstract excerpt

p57KIP2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57KIP2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. Several types of childhood tumors including Wilms' tumor, adrenocortical...

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PMID: 8776593
DOI: 10.1093/hmg/5.6.783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genomic imprinting of human p57KIP2 and its reduced expression in Wilms' tumors.PMID 8776593Read ↗

An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.Semantic proximity Read ↗

Coding mutations in p57KIP2 are present in some cases of Beckwith-Wiedemann syndrome but are rare or absent in Wilms tumors.Semantic proximity Read ↗

Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.Semantic proximity Read ↗

Functional analysis of the p57KIP2 gene mutation in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development.Semantic proximity Read ↗

Assessment of p57(KIP2) gene mutation in Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

p57K1P2 is expressed in Wilms' tumor with LOH of 11p15.5.Semantic proximity Read ↗

Variable Expressivity of the Beckwith-Wiedemann Syndrome in Four Pedigrees Segregating Loss-of-Function Variants of CDKN1C.Semantic proximity Read ↗

Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors.Semantic proximity Read ↗

Human p57(KIP2) defines a new imprinted domain on chromosome 11p but is not a tumour suppressor gene in Wilms tumour.Semantic proximity Read ↗

Molecular genetics of Beckwith-Wiedemann syndromeSemantic proximity Read ↗

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