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Article

Evidence that replication of human neurotropic JC virus DNA in glial cells is regulated by the sequence-specific single-stranded DNA-binding protein Pur alpha

1 Jun 1996

Abstract excerpt

Initiation of polyomavirus DNA replication in eukaryotic cells requires the participation of the viral early protein T antigen, cellular replication factors, and DNA polymerases. The human polyomavirus JC virus (JCV) is the etiologic agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised individuals. This virus exhibits a narrow host range and a tissue specificity...

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PMID: 8648759
DOI: 10.1128/jvi.70.6.4150-4156.1996

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Related research

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Research trail→

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Evidence that replication of human neurotropic JC virus DNA in glial cells is regulated by the sequence-specific single-stranded DNA-binding protein Pur alphaPMID 8648759Read ↗

Reciprocal Interaction between Two Cellular Proteins, Purα and YB-1, Modulates Transcriptional Activity of JCV CY in Glial CellsSemantic proximity Read ↗

Coordinate effects of human immunodeficiency virus type 1 protein Tat and cellular protein Puralpha on DNA replication initiated at the JC virus origin.Semantic proximity Read ↗

Multiple roles for Pur-α in cellular and viral regulationSemantic proximity Read ↗

The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brainSemantic proximity Read ↗

Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein PurαSemantic proximity Read ↗

Glial cells of the human developing brain and B cells of the immune system share a common DNA binding factor for recognition of the regulatory sequences of the human polyomavirus, JCVSemantic proximity Read ↗

SURVEY AND SUMMARY: Puralpha: a multifunctional single-stranded DNA- and RNA-binding proteinSemantic proximity Read ↗

Potential Mechanisms of the Human Polyomavirus JC in Neural OncogenesisSemantic proximity Read ↗

Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activitySemantic proximity Read ↗

Regulation of Human Polyomavirus JC Virus Gene Transcription by AP-1 in Glial CellsSemantic proximity Read ↗

Effects of Tat proteins and Tat mutants of different human immunodeficiency virus type 1 clades on glial JC virus early and late gene transcription.Semantic proximity Read ↗

Human demyelinating disease and the polyomavirus JCVSemantic proximity Read ↗

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