Article
Coordinate effects of human immunodeficiency virus type 1 protein Tat and cellular protein Puralpha on DNA replication initiated at the JC virus origin.
The Journal of general virology - 1 Jul 2001
Daniel Dianne C, Wortman Margaret J, Schiller Robin J, Liu Hong, Gan Li, Mellen Jonathan S, Chang Chun-F, Gallia Gary L, Rappaport Jay, Khalili Kamel, Johnson Edward M
Abstract excerpt
JC virus (JCV) causes progressive multifocal leukoencephalopathy, a demyelinating disease in brains of individuals with AIDS. Previous work has shown that the Tat protein, encoded by human immunodeficiency virus type 1 (HIV-1), can interact with cellular protein Puralpha to enhance both TAR-dependent HIV-1 transcription and JCV late gene transcription. Tat has been shown to activate JCV transcription through...
Topics
- Antigens, Viral, Tumor
- Cyclic AMP Response Element-Binding Protein
- DNA Replication
- DNA-Binding Proteins
- Gene Products, tat
- Humans
- JC Virus
- Mutation
- Neuroglia
- Protein Binding
- Transcription Factors
- Transcription, Genetic