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The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brain

1 Jul 1992

Abstract excerpt

JC virus is a human DNA virus that specifically infects oligodendroglial cells, resulting in a demyelinating disease (progressive multifocal leukoencephalopathy) of the central nervous system of immunosuppressed patients. The host-range restriction of JC virus is controlled at the level of viral gene transcription. To analyze further the determinants of glial specificity, we cloned and sequenced the JC viral...

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PMID: 1322644
DOI: 10.1002/ana.410320112

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The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brainPMID 1322644Read ↗

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