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Article

A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.

The Journal of biological chemistry - 25 May 2018

Debnath Subrata, Kosek Dalibor, Tagad Harichandra D, Durell Stewart R, Appella Daniel H, Acevedo Roderico, Grishaev Alexander, Dyda Fred, Appella Ettore, Mazur Sharlyn J

Abstract excerpt

Metal-dependent protein phosphatases (PPM) are evolutionarily unrelated to other serine/threonine protein phosphatases and are characterized by their requirement for supplementation with millimolar concentrations of Mg2+ or Mn2+ ions for activity in vitro The crystal structure of human PPM1A (also known as PP2Cα), the first PPM structure determined, displays two tightly bound Mn2+ ions in the active site and a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29602904
DOI: 10.1074/jbc.RA117.001213
PMCID: PMC5971455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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