Article
Structure of the kinase domain of Gilgamesh from Drosophila melanogaster.
Acta crystallographica. Section F, Structural biology communications - 1 Apr 2014
Han Ni, Chen CuiCui, Shi Zhubing, Cheng Dianlin
Abstract excerpt
The CK1 family kinases regulate multiple cellular aspects and play important roles in Wnt/Wingless and Hedgehog signalling. The kinase domain of Drosophila Gilgamesh isoform I (Gilgamesh-I), a homologue of human CK1-γ, was purified and crystallized. Crystals of methylated Gilgamesh-I kinase domain with a D210A mutation diffracted to 2.85 Å resolution and belonged to space group P43212, with unit-cell parameters a...
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