Article
A template for the protein kinase family.
Trends in biochemical sciences - 1 Mar 1993
Taylor S S, Knighton D R, Zheng J, Sowadski J M, Gibbs C S, Zoller M J
Abstract excerpt
The crystal structure of the catalytic subunit of cAMP-dependent protein kinase, complexed with ATP and a 20-residue inhibitor peptide, is reviewed and correlated with chemical and genetic data. The striking convergence of the structure with the biochemistry and genetics provides for the first ti...
Topics
- Amino Acid Sequence
- Binding Sites
- Molecular Sequence Data
- Mutation
- Protein Kinases
- Protein Structure, Secondary
- Saccharomyces cerevisiae
- Structure-Activity Relationship