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Article

Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice.

The Journal of clinical investigation - 1 Jun 1996

Vargas G A, Fantino E, George-Nascimento C, Gargus J J, Haigler H T

Abstract excerpt

Patients with hypohidrotic ectodermal dysplasia (HED) and Tabby (Ta) mice lack sweat glands and there is compelling evidence that these phenotypes are caused by mutations in the same highly conserved but unidentified X-linked gene. Previous studies showed that exogenous epidermal growth factor (EGF) reversed the Ta phenotype but the EGF status in HED patients has not been studied at all. Studies reported herein...

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Identifiers

PMID: 8647934
DOI: 10.1172/JCI118689
PMCID: PMC507327

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice.PMID 8647934Read ↗

Interactions between epidermal growth factor and the Tabby mutation in skin.Semantic proximity Read ↗

Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby miceSemantic proximity Read ↗

Molecular aspects of hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development.Semantic proximity Read ↗

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains.Semantic proximity Read ↗

Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis.Semantic proximity Read ↗

Ectodysplasin A protein promotes corneal epithelial cell proliferationSemantic proximity Read ↗

EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice.Semantic proximity Read ↗

Overexpression of Epigen during Embryonic Development Induces Reversible, Epidermal Growth Factor Receptor-Dependent Sebaceous Gland HyperplasiaSemantic proximity Read ↗

X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness.Semantic proximity Read ↗

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.Semantic proximity Read ↗

Attenuation of Mammary Gland Dysplasia and Feeding Difficulties in Tabby Mice by Fetal Therapy.Semantic proximity Read ↗

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