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Article

Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development.

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology - 1 Apr 2003

Jaskoll Tina, Zhou Yan-Min, Trump Gary, Melnick Michael

Abstract excerpt

Hypohidrotic (anhidrotic) ectodermal dysplasia (HED), the most common of the approximately 150 described ectodermal dysplasias, is a disorder characterized by abnormal hair, teeth, sweat glands, and salivary glands. Mutations in the EDA (ectodysplasin-A) and EDAR (ectodysplasin-A receptor) genes are responsible for X-linked and autosomal HED, respectively. Abnormal phenotypes similar to HED are seen in Tabby...

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Identifiers

PMID: 12629675
DOI: 10.1002/ar.a.10045

Genes

EDA
EDAR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development.PMID 12629675Read ↗

Recombinant EDA or Sonic Hedgehog rescue the branching defect in Ectodysplasin A pathway mutant salivary glands in vitro.Semantic proximity Read ↗

Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby miceSemantic proximity Read ↗

Molecular aspects of hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

Ectodysplasin signaling in development.Semantic proximity Read ↗

Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.Semantic proximity Read ↗

Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology.Semantic proximity Read ↗

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains.Semantic proximity Read ↗

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.Semantic proximity Read ↗

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Ectodermal dysplasias: an overview and update of clinical and molecular-functional mechanisms.Semantic proximity Read ↗

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