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Ectodysplasin A protein promotes corneal epithelial cell proliferation

28 Jun 2017

Abstract excerpt

The EDA gene encodes ectodysplasin A (Eda), which if mutated causes X-linked hypohidrotic ectodermal dysplasia (XLHED) disease in humans. Ocular surface changes occur in XLHED patients whereas its underlying mechanism remains elusive. In this study, we found Eda was highly expressed in meibomian glands, and it was detected in human tears but not serum. Corneal epithelial integrity was defective and the thickness...

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PMID: 28655773
DOI: 10.1074/jbc.m117.803809

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