Article
Linkage disequilibrium mapping places the gene causing familial Mediterranean fever close to D16S246.
American journal of human genetics - 1 Mar 1996
Levy E N, Shen Y, Kupelian A, Kruglyak L, Aksentijevich I, Pras E, Balow J E, Linzer B, Chen X, Shelton D A, Gumucio D, Pras M, Shohat M, Rotter J I, Fischel-Ghodsian N, Richards R I, Kastner D L
Abstract excerpt
This report presents refined genetic mapping data for the gene causing familial Mediterranean fever (FMF), a recessively inherited disorder of inflammation. We sampled 65 Jewish, Armenian, and Arab families and typed them for eight markers from chromosome 16p. Using a new algorithm that permits multipoint calculations for a dense map of markers in consanguineous families, we obtained a maximal LOD score of 49.2...
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