Article
Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosus.
Arthritis and rheumatism - 1 Nov 2002
Tsao Betty P, Cantor Rita M, Grossman Jennifer M, Kim Sung K, Strong Noel, Lau Chak S, Chen Chung-Jen, Shen Nan, Ginzler Ellen M, Goldstein Rose, Kalunian Kenneth C, Arnett Frank C, Wallace Daniel J, Hahn Bevra H
Abstract excerpt
OBJECTIVE: Six recent genome scans of different systemic lupus erythematosus (SLE) multiplex family cohorts showed multiple putative susceptibility loci. In the present study, we examined 4 previously identified loci to replicate findings of significant linkage to 1q23 and 16q12, and to support findings of suggestive linkage to 14q21-23 and 20p12 in a cohort of 115 multiethnic nuclear families containing 145...
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