Heat-shock protein 104 expression is sufficient for thermotolerance in yeast.

doi:10.1073/pnas.93.11.5301

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Article

Heat-shock protein 104 expression is sufficient for thermotolerance in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 28 May 1996

Lindquist S, Kim G

Abstract excerpt

In all organisms, mild heat pretreatments induce tolerance to high temperatures. In the yeast Saccharomyces cerevisiae, such pretreatments strongly induce heat-shock protein (Hsp) 104, and hsp104 mutations greatly reduce high-temperature survival, indicating Hsp1O4 plays a critical role in induced thermotolerance. Surprisingly, however, a heat-shock transcription factor mutation (hsf1-m3) that blocks the...

Topics

Estradiol
Gene Expression
Genotype
Heat-Shock Proteins
Hot Temperature
Mutagenesis
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Species Specificity

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Identifiers

PMID: 8643570
DOI: 10.1073/pnas.93.11.5301
PMCID: PMC39240

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