Article
HSP104 required for induced thermotolerance.
Science (New York, N.Y.) - 1 Jun 1990
Sanchez Y, Lindquist S L
Abstract excerpt
A heat shock protein gene, HSP104, was isolated from Saccharomyces cerevisiae and a deletion mutation was introduced into yeast cells. Mutant cells grew at the same rate as wild-type cells and died at the same rate when exposed directly to high temperatures. However, when given a mild pre-heat treatment, the mutant cells did not acquire tolerance to heat, as did wild-type cells. Transformation with the wild-type...
Topics
- Cloning, Molecular
- Fungal Proteins
- Genes, Fungal
- Heat-Shock Proteins
- Hot Temperature
- Mutation
- Restriction Mapping
- Saccharomyces cerevisiae