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Article

Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells.

Cancer research - 15 Mar 1996

Anthoney D A, McIlwrath A J, Gallagher W M, Edlin A R, Brown R

Abstract excerpt

We have examined microsatellite instability and loss of p53 function in human tumor cell line models of acquired anticancer drug resistance. We observe acquisition of an RER(+) phenotype in cell lines selected for resistance to cisplatin or doxorubicin. The majority of independent cisplatin-resistant sublines are RER(+), whereas the parental line shows no evidence of microsatellite instability. Microsatellite...

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PMID: 8640828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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