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Article

Acquisition of chemoresistance in a human ovarian carcinoma cell line is linked to a defect in cell cycle control

9 Nov 1998

Abstract excerpt

Chemoresistance is a major concern in cancer erradication; it involves various mechanisms, including defects in the apoptosis program induced by anticancer drugs. In order to further explore the mechanisms underlying the development of chemoresistance in ovarian carcinoma after cisplatin treatment, we established an in vitro model, mimicking a clinical protocol of administration of cisplatin. Therefore, IGROV1...

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PMID: 9797134
DOI: 10.1002/(sici)1097-0215(19981109)78:4<454::aid-ijc11>3.0.co;2-6

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Source receipt: pubmed, retrieved 7 Sept 2026.

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