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Article

Testicular Germ Cell Tumors Acquire Cisplatin Resistance by Rebalancing the Usage of DNA Repair Pathways

13 Feb 2021

Abstract excerpt

Despite germ cell tumors (GCTs) responding to cisplatin-based chemotherapy at a high rate, a subset of patients does not respond to treatment and have significantly worse prognosis. The biological mechanisms underlying the resistance remain unknown. In this study, by using two TGCT cell lines that have acquired cisplatin resistance after chronic exposure to the drug, we identified some key proteins and mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33668653
DOI: 10.3390/cancers13040787

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