Article
Analysis of microsatellite instability in acquired drug-resistance human tumor cell lines.
Oncology reports - 1 Jan 2000
Picard Samy-Felix, Franco Noreli, Sergent Catherine, Chauffert Bruno, Lizard-Nacol Sarab
Abstract excerpt
Genomic instability characterized as microsatellite instability (MIN) is associated with loss of DNA mismatch repair (MMR) protein. Several studies have shown that loss of DNA MMR protein confers resistance to some interacting DNA chemotherapeutic drugs, but also that exposure of MMR-proficient cells to these drugs can result in loss of MMR protein accompanied by induction of MIN. Such associations were mainly...
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