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Article

Cloning of the mouse insulin receptor substrate-3 (mIRS-3) promoter, and its regulation by p53.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2002

Sciacchitano Salvatore, Orecchio Andrea, Lavra Luca, Misiti Silvia, Giacchini Anna, Zani Massimo, Danese Daniele, Gurtner Aymone, Soddu Silvia, Di Mario Umberto, Andreoli Mario

Abstract excerpt

The insulin receptor susbtrate-3 (IRS-3) is a member of a family of intermediate adapter proteins that function as major intracellular targets for phosphorylation by the activated insulin and IGF-I receptors. Among the four IRS proteins identified so far, IRS-3 exhibits a rather peculiar expression pattern during both the embryonic development and adult life, suggesting a different mechanism of regulation of its...

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PMID: 12089352
DOI: 10.1210/mend.16.7.0881

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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