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Article

Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249.

Molecular and cellular endocrinology - 30 May 2003

Lee Young Ik, Han Yoo Jung, Lee Soo Young, Lee Yoon Ik, Park Sook Kyung, Park Youn Jung, Moon Hyung Bae, Shin Jeh Hoon, Lee Je Ho

Abstract excerpt

The aim of the present study was to investigate the intracellular mediators of the third base mutant of codon 249 in p53 gene (p53mt249) mutation that potentiate IGF-II dependent IGF-I receptor (IGF-IR) signaling. p53mt249 enhanced IGF-II dependent IGF-IR signaling in p53 negative Hep3B hepatoma cells which were specifically prevented by IGF-IR antibody, alpha IR3 and lovastin. p53mt249 increased the number of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12782403
DOI: 10.1016/s0303-7207(03)00117-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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