Generation of activated natural killer (A-NK) cells in patients with chronic myelogenous leukaemia and their role in the in vitro disappearance of BCR/abl-positive targets.

doi:10.1046/j.1365-2141.1996.4991043.x

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Article

Generation of activated natural killer (A-NK) cells in patients with chronic myelogenous leukaemia and their role in the in vitro disappearance of BCR/abl-positive targets.

British journal of haematology - 1 May 1996

Silla L M, Pincus S M, Locker J D, Glover J, Elder E M, Donnenberg A D, Nardi N B, Bryant J, Ball E D, Whiteside T L

Abstract excerpt

Activated natural killer (A-NK) cells, a subset of CD56(dim)CD3- lymphocytes, are obtained from PBMC of normal donors by adherence to plastic and culture in the presence of IL2. In this study we tested the feasibility of generating A-NK cells in patients with Ph+ chronic myeloid leukaemia (CML)....

Topics

Antigens, CD
Base Sequence
Cell Division
Cytotoxicity, Immunologic
Fusion Proteins, bcr-abl
Gene Rearrangement
Humans
Killer Cells, Lymphokine-Activated
Killer Cells, Natural
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphocyte Activation
Molecular Sequence Data

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Phenotype

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8639431
DOI: 10.1046/j.1365-2141.1996.4991043.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8639431-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.