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Article

Definition of early progenitors and functional maturation of human natural killer cells: requirements for cytocidal activity.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1998

Vaz F, Hoffman R, Almeida-Porada G, Ascensao J L

Abstract excerpt

We examined the in vitro development of human natural killer (NK) cells to define the earliest hematopoietic progenitors which could give rise to NK cells. Our data indicates that NK cells arise from the Thy 1+ subpopulations of CD34+ marrow cells. In cultures with IL2 we generated up to 96.5% NK cells from CD34+ Thy 1+ and in cultures with IL7, cells bearing NK cell surface markers were also observed but were...

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Identifiers

PMID: 9577966
DOI: 10.1159/000027994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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