Article
Definition of early progenitors and functional maturation of human natural killer cells: requirements for cytocidal activity.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1998
Vaz F, Hoffman R, Almeida-Porada G, Ascensao J L
Abstract excerpt
We examined the in vitro development of human natural killer (NK) cells to define the earliest hematopoietic progenitors which could give rise to NK cells. Our data indicates that NK cells arise from the Thy 1+ subpopulations of CD34+ marrow cells. In cultures with IL2 we generated up to 96.5% NK...
Topics
- Adult
- Blotting, Southern
- Cell Differentiation
- Cells, Cultured
- Cytotoxicity, Immunologic
- Electrophoresis, Polyacrylamide Gel
- Granzymes
- Hematopoietic Stem Cells
- Humans
- Interleukin-2
- Interleukin-7
- Killer Cells, Natural
- Phenotype
- Polymerase Chain Reaction
- Serine Endopeptidases