Genesis of human oncolytic natural killer cells from primitive CD34+CD33- bone marrow progenitors.

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Article

Genesis of human oncolytic natural killer cells from primitive CD34+CD33- bone marrow progenitors.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1993

Lotzová E, Savary C A, Champlin R E

Abstract excerpt

We have found that fully functional CD56+CD3- NK cells can be generated from highly enriched populations of CD34+ human bone marrow progenitors in long term bone marrow culture (LTBMC) with IL-2. Strong lytic activity against K-562 cells was observed after 2 to 3 weeks of culture and coincided wi...

Topics

Antigens, CD
Antigens, CD34
Antigens, Differentiation, Myelomonocytic
Cells, Cultured
Cytotoxicity, Immunologic
Hematopoiesis
Hematopoietic Stem Cells
Humans
Interleukin-2
Killer Cells, Natural
Phenotype
Sialic Acid Binding Ig-like Lectin 3

Source

Open in PubMed

Identifiers

PMID: 7685792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7685792-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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