Article
Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within gag/pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.
Virology - 15 May 1996
Barrie K A, Perez E E, Lamers S L, Farmerie W G, Dunn B M, Sleasman J W, Goodenow M M
Abstract excerpt
Reduced sensitivity of human immunodeficiency virus type 1 (HIV-1) to protease inhibitors is associated with multiple amino acid substitutions in the virus-encoded protease. The combination of changes that contribute to drug resistance is dependent in part upon the amino acid residues comprising...
Topics
- Alleles
- Amino Acid Sequence
- Antiviral Agents
- Base Sequence
- Binding Sites
- Capsid
- Capsid Proteins
- Child
- Cross-Sectional Studies
- DNA Primers
- Gene Products, gag
- Gene Products, pol
- Genetic Variation
- HIV Infections