Article
Compensatory mutations at the HIV cleavage sites p7/p1 and p1/p6-gag in therapy-naive and therapy-experienced patients.
Antiviral therapy - 1 Jan 2006
Verheyen Jens, Litau Elena, Sing Tobias, Däumer Martin, Balduin Melanie, Oette Mark, Fätkenheuer Gerd, Rockstroh Jürgen K, Schuldenzucker Ulrike, Hoffmann Daniel, Pfister Herbert, Kaiser Rolf
Abstract excerpt
BACKGROUND: Mutations in the genome of HIV conferring drug resistance are a major reason for the failure of antiretroviral therapy, but they often compromise viral fitness. Protease (PR) cleavage site (CS) mutations could compensate for impaired replication capacity of drug-resistant viruses. PATIENTS AND METHODS: We analysed the cleavage sites p1/p7 and p1/p6-gag of 500 HIV-1 subtype B infected patients. The...
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